Perturbed proteostasis in autism spectrum disorders
نویسندگان
چکیده
منابع مشابه
Explorer Perturbed proteostasis in autism spectrum disorders
Dynamic changes in synaptic strength rely on de novo protein synthesis and protein degradation by the ubiquitin proteasome system (UPS). Disruption of either of these cellular processes will result in significant impairments in synaptic plasticity and memory formation. Mutations in several genes encoding regulators of mRNA translation and members of the UPS have been associated with an increase...
متن کاملPerturbed proteostasis in autism spectrum disorders
Dynamic changes in synaptic strength rely on de novo protein synthesis and protein degradation by the ubiquitin proteasome system (UPS). Disruption of either of these cellular processes will result in significant impairments in synaptic plasticity and memory formation. Mutations in several genes encoding regulators of mRNA translation and members of the UPS have been associated with an increase...
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how to cite this article: mohammadi mr, salmanian m, akhondzadeh sh. autism spectrum disorders in iran. iranian journal of child neurology2011;5(4):1-9. objective autistic disorder, asperger syndrome, and pdd-not otherwise specified are subsets of autism spectrum disorders (asds), which are characterized by impairments in social communication and stereotyped behavior. this article reviews the p...
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Background: The prevalence of autism spectrum disorder (ASD) as a child neurodevelopmental disorder has increased significantly during the past 3 decades worldwide and in Iran. This chronic disease does not cause premature death and there is no definitive treatment. Thus, the cost of ASD is extremely heavy and overwhelming. The purpose of this study is to calculate the economic burden of ASD in...
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Objective: The present study has been carried out to compare the social competence in two groups of students with Autism Disorder (AD) and Learning Disorders (LD). Methods: This research was a kind of descriptive research with 2 comparative groups. 90 learning and Autistic disorder students aged 10 to 13 years (45 LD & 45 AD) were selected randomly as a statistical sample. For the assessment...
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ژورنال
عنوان ژورنال: Journal of Neurochemistry
سال: 2016
ISSN: 0022-3042
DOI: 10.1111/jnc.13723